R. Prantil-Baun

Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip

This paper develops a human vagina-on-a-chip model to study vaginal microbiome-host interactions and their effects on health outcomes.

Establishment of physiologically relevant oxygen gradients in microfluidic organ chips

This paper establishes a method to create physiologically relevant oxygen gradients in a microfluidic intestine-on-a-chip model, supporting stable oxygen levels and intestinal barrier integrity.

Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity

This paper introduces self-assembling short duplex RNAs that induce interferon production and inhibit multiple respiratory viruses.

Enteric coronavirus infection and treatment modeled with an immunocompetent human intestine-on-a-chip

This paper uses an intestine-on-a-chip model to study NL63 coronavirus infection effects on the human intestine and tests antiviral treatments.

Predicting drug concentrations in PDMS microfluidic organ chips

This paper develops a simulation and experimental method to predict drug concentration profiles in PDMS microfluidic organ chips without prior knowledge of log P or diffusion rates.

Lymphoid follicle formation and human vaccination responses recapitulated in an organ-on-a-chip

This paper demonstrates the formation of lymphoid follicles in a human organ-on-a-chip model and shows improved vaccine responses compared to 2D cultures.

Mechanical control of innate immune responses against viral infection revealed in a human Lung Alveolus Chip

This study shows that mechanical breathing motions suppress viral replication by enhancing innate immune responses in a human Lung Alveolus Chip model.

Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics

This paper demonstrates the use of human organ chips to rapidly repurpose therapeutics for viral pandemics, identifying amodiaquine as a potential treatment for SARS-CoV-2.

Human colon-on-a-chip enables continuous in vitro analysis of colon mucus layer accumulation and physiology

This study develops a human colon-on-a-chip model that replicates the mucus bilayer structure and function, enabling real-time non-invasive analysis of mucus layer dynamics.

Discovery of influenza drug resistance mutations and host therapeutic targets using a human airway chip

The paper uses a human airway chip to discover influenza drug resistance mutations and identify host therapeutic targets for antiviral drugs.

Species-specific enhancement of enterohemorrhagic E. Coli pathogenesis mediated by microbiome metabolites

The paper identifies human gut microbiome metabolites that enhance EHEC pathogenesis in a human colonic organ chip model, contributing to species-specific susceptibility.

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function, drug penetration, and antibody shuttling properties

This paper develops a BBB chip that maintains high barrier function for a week, enabling better drug and antibody testing.