Author

D. B. Chou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:organoid / primary culture· 2 Assay:proteomics· 2 Research Focus:differential expression· 1

Frequent Co-Authors

A. Sontheimer-Phelps· 3 shared D. E. Ingber· 3 shared R. Prantil-Baun· 3 shared A. Tovaglieri· 2 shared C. A. Richmond· 2 shared C. F. Ng· 2 shared D. T. Breault· 2 shared E. Calamari· 2 shared

Activity by Year

2018-2019 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBioengineering

A. Sontheimer-Phelps

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Human colon-on-a-chip enables continuous in vitro analysis of colon mucus layer accumulation and physiology

A. Sontheimer-Phelps, D. B. Chou, A. Tovaglieri, T. C. Ferrante, T. Duckworth, C. Fadel, V. Frismantas, S. Jalili Firoozinezhad, M. Kasendra, E. Stas, J. C. Weaver, C. A. Richmond, O. Levy, R. Prantil-Baun, D. T. Breault, D. E. Ingber

This study develops a human colon-on-a-chip model that replicates the mucus bilayer structure and function, enabling real-time non-invasive analysis of mucus layer dynamics.

bioRxiv · Aug 20, 2019Cell Biology

A robotic platform for fluidically-linked human body-on-chips experimentation

R. Novak, M. Ingram, S. Clauson, D. Das, A. Delahanty, A. Herland, B. Maoz, S. S. F. Jeanty, M. R. Somayaji, M. Burt, E. Calamari, A. Chalkiadaki, A. Cho, Y. Choe, D. B. Chou, , B. Swenor

The paper introduces an automated platform for culturing and analyzing human Organ Chips, demonstrating its ability to maintain organ function and predict tracer distribution using a computational model.

bioRxiv · Mar 6, 2019 · PreprintBioengineering

Species-specific enhancement of enterohemorrhagic E. Coli pathogenesis mediated by microbiome metabolites

A. Tovaglieri, A. Sontheimer-Phelps, A. Geirnaert, R. Prantil-Baun, D. M. Camacho, D. B. Chou, S. Jalili-Firoozinezhad, T. de Wouters, M. Kasendra, M. Super, M. Cartwright, C. A. Richmond, D. T. Breault, C. Lacroix, D. E. Ingber

The paper identifies human gut microbiome metabolites that enhance EHEC pathogenesis in a human colonic organ chip model, contributing to species-specific susceptibility.

bioRxiv · Jan 7, 2019Bioengineering

Probiotic Associated Therapeutic Curli Hybrids (PATCH)

P. Praveschotinunt, A. M. Duraj-Thatte, I. Gelfat, F. Bahl, D. B. Chou, N. S. Joshi

This study genetically engineers Escherichia coli to produce an anti-inflammatory matrix of curli nanofibers fused with trefoil factors, showing protective effects against colitis in mice.

bioRxiv · Nov 7, 2018 · PreprintBioengineering

Human bone marrow disorders recapitulated in vitro using organ chip technology

D. B. Chou, V. Frismantas, Y. Milton, R. David, P. Pop-Damkov, D. Ferguson, A. MacDonald, O. Vargel Bolukbasi, C. E. Joyce, L. S. Moreira Teixeira, A. Rech, A. Jiang, E. Calamari, S. Jalili-Firoozinezhad, C. F. Ng, , D. E. Ingber

The paper describes a Bone Marrow-on-a-Chip model that mimics bone marrow function and disease states, including drug and radiation responses and Shwachman-Diamond Syndrome abnormalities.

bioRxiv · Nov 1, 2018 · PreprintBioengineering