Author

A. Alpsoy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

C. R. Vakoc· 2 shared D. Skopelitis· 2 shared A. Bavari· 1 shared A. C. Schier· 1 shared A. L. Thorpe· 1 shared C. A. Briney· 1 shared C. Tonelli· 1 shared D. A. Tuveson· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

C. R. Vakoc

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3 papers

Recent·Most cited

MARK2/MARK3 kinases are catalytic co-dependencies of YAP/TAZ in human cancer

O. Klingbeil, D. Skopelitis, C. Tonelli, A. Alpsoy, F. Minicozzi, D. Aggarwal, S. Russo, T. Ha, O. E. Demerdash, D. L. Spector, D. A. Tuveson, P. Cifani, C. R. Vakoc

This study identifies MARK2/3 as essential kinases for YAP/TAZ function in cancer and shows their inhibition can restore Hippo pathway tumor suppression.

bioRxiv · Feb 26, 2024Cancer Biology

Marker-based CRISPR screening reveals a MED12-p63 interaction that activates basal identity in pancreatic ductal adenocarcinoma

D. Maia-Silva, A. C. Schier, D. Skopelitis, V. Kechejian, A. Alpsoy, J. Liverpool, D. J. Taatjes, C. R. Vakoc

The paper identifies MED12-p63 interaction as a driver of basal identity in PDAC through genetic screens and biochemical analysis.

bioRxiv · Oct 24, 2023 · PreprintCancer Biology

A chemoproteomic portrait of the oncometabolite fumarate

R. A. Kulkarni, D. W. Bak, D. Wei, S. E. Bergholtz, C. A. Briney, J. H. Shrimp, A. L. Thorpe, A. Bavari, A. Alpsoy, M. Levy, L. Florens, M. P. Washburn, E. C. Dykhuizen, N. Frizzell, E. Weerapana, , J. L. Meier

This study maps fumarate's covalent targets using chemoproteomic probes and identifies cysteine residues affected by fumarate or FH mutations in HLRCC cells.

bioRxiv · Mar 22, 2018Cancer Biology