Author

D. Munoz-Espin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. Macias· 3 shared E. Gonzalez-Gualda· 2 shared H.-L. Ou· 2 shared M. Denholm· 2 shared A. B. Popov· 1 shared A. Dyas· 1 shared A. G. Baker· 1 shared A. Vernet· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

D. Macias

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Failed reprogramming of transformed cells due to induction of apoptosis and senescence impairs tumor progression in lung cancer

P. Pedrosa, Z. Zang, D. Macias, J. Ge, M. Denholm, A. Dyas, V. Nunez-Quintela, V. Estevez-Souto, P. Lado-Fernandez, P. Gonzalez, M. Gomez, J. E. Martin, S. Da Silva-Alvarez, D. Munoz-Espin, M. Collado

The paper shows that OSKM expression in lung cancer cells induces apoptosis and senescence, limiting tumor growth and reducing tumor burden in vivo.

bioRxiv · Oct 19, 2023 · PreprintCell Biology

In Vivo Monitoring of Cellular Senescence by Photoacoustic and Fluorescence Imaging Utilizing a Nanostructured Organic Probe

A. G. Baker, H.-L. Ou, M. Hartono, A. B. Popov, E. L. Brown, J. Joseph, M. Golinska, C. Sanghera, E. Gonzalez-Gualda, D. Macias, T. R. Else, H. F. Greer, A. Vernet, S. E. Bohndiek, L. Fruk, D. Munoz-Espin

This study develops a nanostructured organic probe, NanoJaggs, for in vivo monitoring of cellular senescence using photoacoustic and fluorescence imaging, showing specificity for chemotherapy-induced senescence in tumors.

bioRxiv · Jul 12, 2023 · PreprintCancer Biology

A tumour-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer

E. Gonzalez-Gualda, D. Macias, S. Morsli, E. Martin, H.-L. Ou, M. Denholm, I. Olan, R. Hoffmann, M. Dane, D. Veroutis, G. Medrano, F. Mulero, C. Martins, M. Barbacid, V. Gorgoulis, , D. Munoz-Espin

This study shows platinum chemotherapy induces a senescent secretome in lung cancer that promotes tumor growth via the TGFβR1/Akt-mTOR axis, and targeting this pathway reduces tumor burden.

bioRxiv · Aug 1, 2022 · PreprintCancer Biology