Author

S. E. Bohndiek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Biophysics· 2 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:imaging· 6 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:clustering· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

E. L. Brown· 4 shared J. Joseph· 3 shared L. Hacker· 3 shared P. W. Sweeney· 3 shared T. L. Lefebvre· 3 shared J. Gröhl· 2 shared J. Weber· 2 shared K. N. Baumann· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBioengineering

E. L. Brown

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The in vitro dynamics of pseudo-vascular network formation.

M.-E. Oraiopoulou, D.-L. Couturier, E. V. Bunce, I. Cannell, M. Golinska, G. J. Hannon, V. Sakkalis, S. E. Bohndiek

This study develops a framework to monitor and analyze the dynamic formation and dissolution of pseudo-vascular networks in vitro using time-resolved microscopy and image analysis, showing melanoma cells form the most stable networks and respond to specific drug treatments.

bioRxiv · Nov 2, 2023 · PreprintCancer Biology

In Vivo Monitoring of Cellular Senescence by Photoacoustic and Fluorescence Imaging Utilizing a Nanostructured Organic Probe

A. G. Baker, H.-L. Ou, M. Hartono, A. B. Popov, E. L. Brown, J. Joseph, M. Golinska, C. Sanghera, E. Gonzalez-Gualda, D. Macias, T. R. Else, H. F. Greer, A. Vernet, S. E. Bohndiek, L. Fruk, D. Munoz-Espin

This study develops a nanostructured organic probe, NanoJaggs, for in vivo monitoring of cellular senescence using photoacoustic and fluorescence imaging, showing specificity for chemotherapy-induced senescence in tumors.

bioRxiv · Jul 12, 2023 · PreprintCancer Biology

Unsupervised segmentation of 3D microvascular photoacoustic images using deep generative learning

P. W. Sweeney, L. Hacker, T. L. Lefebvre, E. L. Brown, J. Gröhl, S. E. Bohndiek

This paper introduces an unsupervised deep learning model for segmenting 3D vascular networks from photoacoustic images without requiring manual labels.

bioRxiv · Apr 30, 2023Biophysics

Performance evaluation of mesoscopic photoacoustic imaging

L. Hacker, E. L. Brown, T. L. Lefebvre, P. W. Sweeney, S. E. Bohndiek

This study evaluates the performance of a commercial photoacoustic mesoscopy system, showing high precision with low coefficients of variation but highlighting challenges in imaging vessel-like structures.

bioRxiv · Oct 17, 2022Bioengineering

Quantification of vascular networks in photoacoustic mesoscopy

E. L. Brown, T. L. Lefebvre, P. W. Sweeney, B. Stolz, J. Gröhl, L. Hacker, Z. Huang, H. Harrington, H. Byrne, S. E. Bohndiek

This paper develops a framework to quantify 3D vascular networks using mesoscopic photoacoustic imaging and evaluates segmentation methods for accuracy.

bioRxiv · Nov 22, 2021Bioengineering

DNA-based nanocarriers to enhance the optoacoustic contrast of tumors in vivo

J. Joseph, K. N. Baumann, A. Postigo, L. Bollepalli, S. E. Bohndiek, S. Hernandez-Ainsa

This study introduces DNA-based nanocarriers to improve optoacoustic tumor imaging by enhancing signal generation and prolonging circulation time of near infrared dyes.

bioRxiv · Aug 7, 2020Bioengineering

ThX - A next-generation probe for the early detection of amyloid aggregates

L.-M. Needham, J. Weber, J. A. Varela, J. W. B. Fyfe, D. T. Do, C. K. Xu, B. Keenlyside, R. Cliffe, D. Klenerman, C. M. Dobson, C. A. Hunter, S. E. Bohndiek, T. N. Snaddon, S. F. Lee

This paper introduces ThX, a new fluorescent probe for detecting amyloid aggregates, showing improved brightness and binding affinity over ThT.

bioRxiv · Jul 24, 2019Biophysics

Photoacoustic molecular rulers based on DNA nanostructures

J. Joseph, P. Koehler, T. J. Zuehlsdorff, D. J. Cole, K. N. Baumann, J. Weber, S. E. Bohndiek, S. Hernandez-Ainsa

This paper demonstrates the use of photoacoustic tomography to measure distance-dependent FRET in DNA nanostructures at centimeter depths, validating their potential to enhance photoacoustic signal generation.

bioRxiv · Apr 26, 2017Bioengineering