Author

S. A. Harris

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Approach:experimental assay· 3 Organism:human· 3 Assay:cryo-EM· 2 Approach:deep learning· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2

Frequent Co-Authors

D. J. Read· 2 shared G. Wells· 2 shared H. McShane· 2 shared M. K. O'Shea· 2 shared O. G. Harlen· 2 shared R. Tanner· 2 shared A. Anandkumar· 1 shared A. Brace· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBiophysics

D. J. Read

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Exploiting cryo-EM structures of actomyosin-5a to reveal the physical properties of its lever

M. S. C. Gravett, D. P. Klebl, O. G. Harlen, D. J. Read, S. A. Harris, S. P. Muench, M. Peckham

This study uses cryo-EM and molecular dynamics to determine the structure and physical properties of Myo5a's lever, revealing its working stroke and implications for its walking mechanism.

bioRxiv · Mar 19, 2023Biophysics

Intelligent Resolution: Integrating Cryo-EM with AI-driven Multi-resolution Simulations to Observe the SARS-CoV-2 Replication-Transcription Machinery in Action

A. Trifan, D. Gorgun, Z. Li, A. Brace, M. Zvyagin, H. Ma, A. R. Clyde, D. A. Clark, M. Salim, D. Hardy, T. Burnley, L. Huang, J. McCalpin, M. Emani, H. Yoo, , A. Ramanathan

This study develops an AI-driven multi-resolution simulation workflow to study SARS-CoV-2 RTC dynamics, combining cryo-EM with mesoscale simulations and AI methods.

bioRxiv · Oct 9, 2021 · PreprintBiophysics

Induction of specific antibodies, IgG-secreting plasmablasts and memory B cells following BCG vaccination

J. Bitencourt, M. Wilkie, M. P. Peralta Alvarez, A. Jacobs, D. Wright, S. A. Harris, S. G. Smith, S. Elias, A. White, S. Sharpe, M. K. O'Shea, H. McShane, R. Tanner

This study investigates the BCG vaccine's induction of specific antibodies, IgG-secreting plasmablasts, and memory B cells in humans and macaques, highlighting the potential role of humoral immunity in TB vaccine development.

bioRxiv · Feb 18, 2021 · PreprintImmunology

Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides

A. L. B. Pyne, A. Noy, K. Main, V. Velasco-Berrelleza, M. M. Piperakis, L. A. Mitchenhall, F. M. Cugliandolo, J. G. Beton, C. E. M. Stevenson, B. W. Hoogenboom, A. D. Bates, A. Maxwell, S. A. Harris

This study uses AFM and MD simulations to analyze how DNA supercoiling affects structure and triplex-forming oligonucleotide binding at base-pair resolution.

bioRxiv · Jan 7, 2021Biophysics

A generalised mechano-kinetic model for use in multiscale simulation protocols.

B. S. Hanson, L. Dougan, O. G. Harlen, S. A. Harris, D. J. Read

This paper introduces a generalised mechano-kinetic model to simulate biophysical systems efficiently by coupling dynamic and kinetic processes across different time scales.

bioRxiv · Nov 17, 2020 · PreprintBiophysics

Modelling the active SARS-CoV-2 helicase complex as a basis for structure-based inhibitor design

D. Berta, M. Badaoui, P. J. Buigues, S. A. Martino, A. Pisliakov, N. Elghobashi-Meinhardt, G. Wells, S. A. Harris, E. Frezza, E. Rosta

This study models the active SARS-CoV-2 helicase complex to provide structural insights for inhibitor design.

bioRxiv · Nov 3, 2020Biochemistry

Cytomegalovirus infection is a risk factor for TB disease in Infants

J. Muller, R. Tanner, M. Matsumiya, M. A. Snowden, B. Landry, I. Satti, S. A. Harris, M. K. O'Shea, L. Stockdale, L. Marsay, A. Chomka, R. Harrington-Kandt, Z.-R. Manjaly Thomas, V. Naranbhai, E. Stylianou, , H. A. Fletcher

This study identifies CMV infection as a risk factor for TB disease in infants by linking CMV-induced IFN-gamma responses to immune activation and increased TB risk.

bioRxiv · May 6, 2019Immunology