Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike
C. J. Bracken, S. A. Lim, P. Solomon, N. J. Rettko, D. P. Nguyen, B. S. Zha, K. Schaefer, J. R. Byrnes, J. Zhou, I. Lui, J. Liu, K. Pance, QCRG Structural Biology Consortium, X. X. Zhou, K. K. Leung, J. A. Wells
This paper identifies and engineers multivalent human VH domains that neutralize SARS-CoV-2 by targeting distinct epitopes on the Spike protein's ACE2 binding interface, showing increased affinity and potency.
bioRxiv · Aug 8, 2020 · PreprintBioengineering