Author

N. J. Rettko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. A. Wells· 4 shared I. Lui· 3 shared K. K. Leung· 3 shared P. Solomon· 3 shared S. A. Lim· 3 shared X. X. Zhou· 3 shared B. S. Zha· 2 shared J. Liu· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersBioengineering

J. A. Wells

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Author profile →

4 papers

Recent·Most cited

Secreted HLA Fc-Fusion Profiles Immunopeptidome in Hypoxic PDAC and Cellular Senescence

N. J. Rettko, L. L. Kirkemo, J. A. Wells

This paper introduces a novel sHLA Fc-fusion method to identify HLA-associated peptides in hypoxic PDAC and senescence, revealing >30,000 unique peptides, many previously unreported.

bioRxiv · Apr 10, 2023Immunology

Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike

C. J. Bracken, S. A. Lim, P. Solomon, N. J. Rettko, D. P. Nguyen, B. S. Zha, K. Schaefer, J. R. Byrnes, J. Zhou, I. Lui, J. Liu, K. Pance, QCRG Structural Biology Consortium, X. X. Zhou, K. K. Leung, J. A. Wells

This paper identifies and engineers multivalent human VH domains that neutralize SARS-CoV-2 by targeting distinct epitopes on the Spike protein's ACE2 binding interface, showing increased affinity and potency.

bioRxiv · Aug 8, 2020 · PreprintBioengineering

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

A. Glasgow, J. E. Glasgow, D. Limonta, P. Solomon, I. Lui, Y. Zhang, M. A. Nix, N. J. Rettko, S. A. Lim, S. Zha, R. Yamin, K. Kao, O. S. Rosenberg, J. V. Ravetch, A. P. Wiita, , J. A. Wells

This paper describes engineered ACE2 receptor traps that potently neutralize SARS-CoV-2 by blocking viral entry through enhanced binding affinity.

bioRxiv · Jul 31, 2020Bioengineering

Trimeric SARS-CoV-2 Spike interacts with dimeric ACE2 with limited intra-Spike avidity

I. Lui, X. X. Zhou, S. A. Lim, S. Elledge, P. Solomon, N. J. Rettko, B. S. Zha, L. L. Kirkemo, J. A. Gramespacher, J. Liu, F. Muecksch, J. C. C. Lorenzi, F. Schmidt, Y. Weisblum, D. F. Robbiani, , J. A. Wells

This study investigates the interaction between SARS-CoV-2 Spike and ACE2, showing that dimeric ACE2 binds with high affinity to Spike and blocks viral entry, with limited intra-Spike avidity.

bioRxiv · May 21, 2020 · PreprintBiochemistry