J. R. Byrnes

PVRL2 Suppresses Anti-tumor Immunity Through PVRIG- and TIGIT-Independent Pathways

This study shows PVRL2 suppresses anti-tumor immunity independently of PVRIG and TIGIT, with deletion reducing tumor growth more than PD-L1 loss.

Site-specific proximity labeling at single residue resolution for identification of protein partners in vitro and on cells

This paper optimizes a high-resolution proximity labeling method to identify protein partners of HER2 on cells and in vitro, finding 20 high-confidence neighbors enriched compared to non-specific labeling.

Cell-surface tethered promiscuous biotinylators enable small-scale surface proteomics of human exosomes

This paper introduces two methods for rapid, small-scale cell surface biotinylation using tethered enzymes, enabling surface proteome analysis of cells and exosomes with high coverage and quantification of 1,020 surface proteins.

Hypoxia is a dominant remodeler of the CD8+ T cell surface proteome relative to activation and regulatory T cell-mediated suppression

This study compares how hypoxia and regulatory T cells affect the CD8+ T cell surface proteome, finding hypoxia has a more significant impact than Treg-mediated suppression.

Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike

This paper identifies and engineers multivalent human VH domains that neutralize SARS-CoV-2 by targeting distinct epitopes on the Spike protein's ACE2 binding interface, showing increased affinity and potency.

Mapping proteolytic neo-N termini at the surface of living cells

The paper develops a method to capture and sequence cell surface N termini in live cells, revealing changes in neo-N termini abundance in response to proteolytic stimuli.