Identifying targetable metabolic dependencies across colorectal cancer progression
D. N. Legge, E. Stanko, A. K. Holt, C. J. Bull, T. J. Collard, M. Kollareddy, J. Bellamy, S. Groves, E. H. Ma, E. Hazelwood, D. Qualtrough, B. Amulic, K. N. Malik, A. C. Williams, N. Jones, E. E. Vincent
This study identifies asparagine synthesis as a metabolic vulnerability in late-stage colorectal cancer cells, showing that blocking asparagine synthetase inhibits their proliferation.
bioRxiv · Mar 23, 2022Cancer Biology