Author

A. K. Holt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. C. Williams· 2 shared D. N. Legge· 2 shared E. E. Vincent· 2 shared M. Kollareddy· 2 shared N. Jones· 2 shared T. J. Collard· 2 shared A. J. Hoskin· 1 shared A. K. Najumudeen· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

A. C. Williams

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2 papers

Recent·Most cited

Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

A. K. Holt, A. K. Najumudeen, A. J. Hoskin, D. N. Legge, E. M. H. Mortensson, D. J. Flanagan, N. Jones, M. Kollareddy, T. J. Collard, P. Timms, O. J. Sansom, A. C. Williams, E. E. Vincent

This study shows aspirin reprograms colorectal cancer cell metabolism and increases sensitivity to glutaminase inhibition, suggesting potential for improved metabolic therapies in CRC.

bioRxiv · Aug 24, 2022Cancer Biology

Identifying targetable metabolic dependencies across colorectal cancer progression

D. N. Legge, E. Stanko, A. K. Holt, C. J. Bull, T. J. Collard, M. Kollareddy, J. Bellamy, S. Groves, E. H. Ma, E. Hazelwood, D. Qualtrough, B. Amulic, K. N. Malik, A. C. Williams, N. Jones, E. E. Vincent

This study identifies asparagine synthesis as a metabolic vulnerability in late-stage colorectal cancer cells, showing that blocking asparagine synthetase inhibits their proliferation.

bioRxiv · Mar 23, 2022Cancer Biology