Author

J. S. Knight

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. X. O'Riordan· 5 shared B. H. Abuaita· 4 shared A.-L. E. Lawrence· 3 shared G. J. Sule· 3 shared B. Bons· 2 shared C. E. Wobus· 2 shared C. Fields· 2 shared D. R. Hill· 2 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

M. X. O'Riordan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The IRE1α-XBP1 signaling axis promotes glycolytic reprogramming in response to inflammatory stimuli

B. C. English, H. P. Savage, S. P. Mahan, V. E. Diaz-Ochoa, B. M. Young, B. H. Abuaita, G. J. Sule, J. S. Knight, M. X. O'Riordan, A. J. Baumler, R. M. Tsolis

This study shows that the IRE1α-XBP1 signaling axis enhances glycolysis in macrophages during inflammation, but pathway activation alone is not sufficient to increase glycolytic rates.

bioRxiv · Oct 19, 2022Immunology

Neutrophils prime unique transcriptional responses in intestinal organoids during infection with nontyphoidal Salmonella enterica serovars

A.-L. E. Lawrence, R. P. Berger, D. R. Hill, S. Huang, V. K. Yadagiri, B. Bons, C. Fields, J. S. Knight, C. E. Wobus, J. R. Spence, V. B. Young, B. H. Abuaita, M. X. O'Riordan

This study investigates how human neutrophils modulate host responses to two nontyphoidal Salmonella serovars using intestinal organoids and transcriptomics.

bioRxiv · Aug 9, 2022 · PreprintImmunology

Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II assembly and stability

M. B. Reynolds, H. S. Hong, B. C. Michmerhuizen, A.-L. E. Lawrence, L. Zhang, J. S. Knight, C. A. Lyssiotis, B. H. Abuaita, M. X. O'Riordan

The paper shows cardiolipin regulates Complex II assembly and stability in macrophages, linking it to inflammatory metabolic reprogramming.

bioRxiv · Jul 27, 2022 · PreprintImmunology

Human neutrophils direct epithelial cell extrusion to enhance intestinal epithelial host defense during Salmonella infection

A.-L. E. Lawrence, R. P. Berger, D. R. Hill, S. Huang, V. K. Yadagiri, B. Bons, C. Fields, G. J. Sule, J. S. Knight, C. E. Wobus, J. Spence, V. Young, M. X. O'Riordan, B. Abuaita

This study shows human neutrophils enhance intestinal epithelial cell extrusion to reduce Salmonella burden during infection, beyond direct antimicrobial activity.

bioRxiv · Mar 25, 2022Microbiology

The IRE1α stress signaling axis is a key regulator of neutrophil antimicrobial effector function

B. H. Abuaita, G. J. Sule, T. L. Schultz, F. Gao, J. S. Knight, M. X. O'Riordan

The paper shows that IRE1α activation enhances neutrophil antimicrobial functions like IL-1β production, NET formation, and MRSA killing.

bioRxiv · Aug 22, 2019Immunology