Author

L. J. Frye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:non-human primate· 4 Approach:experimental assay· 3 Approach:deep learning· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. G. White· 5 shared J. L. Flynn· 5 shared H. J. Borish· 3 shared J. A. Tomko· 3 shared P. L. Lin· 3 shared P. Maiello· 3 shared C. A. Scanga· 2 shared C. Scanga· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersImmunology

A. G. White

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Distributable, Metabolic PET Reporting of Tuberculosis

R. M. N. Khan, Y.-M. Ahn, G. A. Marriner, L. E. Via, F. D'Hooge, S. S. Lee, N. Yang, F. Basuli, A. G. White, J. A. Tomko, L. J. Frye, C. A. Scanga, D. M. Weiner, M. L. Sutphen, D. M. Schimel, , B. G. Davis

This paper introduces [18F]FDT, a PET tracer that specifically images Mycobacterium tuberculosis lesions and monitors treatment, enabling global access through a simple synthesis method from [18F]FDG.

Nature Communications · Jun 27, 2024Peer-reviewedBiochemistry

Optimizing tuberculosis treatment efficacy: comparing the standard regimen with Moxifloxacin-containing regimens

M. Budak, J. M. Cicchese, P. Maiello, H. J. Borish, A. G. White, H. B. Chishti, J. Tomko, L. J. Frye, D. Fillmore, K. Kracinovsky, J. Sakal, C. A. Scanga, P. L. Lin, V. Dartois, J. J. Linderman, , D. E. Kirschner

This study compares standard TB treatment with moxifloxacin-containing regimens using computational models and experimental validation to identify more effective and patient-friendly treatment options.

bioRxiv · Dec 18, 2022Pharmacology & Toxicology

T cell transcription factor expression evolves as adaptive immunity matures in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques

N. L. Grant, P. Maiello, E. Klein, P. L. Lin, H. J. Borish, J. Tomko, L. J. Frye, A. G. White, D. E. Kirschner, J. T. Mattila, J. L. Flynn

This study tracks T cell transcription factor expression in granulomas of Mtb-infected macaques over time, showing increased T-bet+ T cells correlate with reduced bacterial burden.

bioRxiv · Jan 25, 2022 · PreprintImmunology

Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control

H. P. Gideon, T. K. Hughes, C. N. Tzouanas, M. H. Wadsworth, A. A. Tu, T. M. Gierahn, J. M. Peters, F. H. Hopkins, J.-R. Wei, C. Kummerlowe, N. L. Grant, K. Nargan, J. Phuah, H. J. Borish, P. Maiello, , A. K. Shalek

The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.

bioRxiv · Oct 24, 2020 · PreprintImmunology

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and prolonged shedding of infectious virus from both respiratory and gastrointestinal tracts

A. L. Hartman, S. Nambulli, C. M. McMillen, A. G. White, N. Tilston-Lunel, J. R. Albe, E. L. Cottle, M. D. Dunn, L. J. Frye, T. H. Gilliland, E. L. Olsen, K. J. O'Malley, M. M. Schwarz, J. A. Tomko, R. C. Walker, , W. P. Duprex

bioRxiv · Jun 20, 2020Microbiology