Author

D. Watkins

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:fluorescence / live-cell microscopy· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Woolston· 2 shared B. Griffiths· 2 shared D. Cunningham· 2 shared I. Chau· 2 shared L. J. Barber· 2 shared M. Gerlinger· 2 shared N. Starling· 2 shared S. Rao· 2 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. Woolston

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mutational processes impact the evolution of anti-EGFR antibody resistance in colorectal cancer

A. Woolston, L. J. Barber, B. Griffiths, N. Matthews, S. Rao, D. Watkins, I. Chau, N. Starling, D. Cunningham, M. Gerlinger

The paper investigates mutational processes in colorectal cancer resistance to anti-EGFR antibodies, finding that mutational Signature 17 predicts resistance evolution and shorter progression-free survival.

bioRxiv · May 7, 2020Cancer Biology

The effect of proximity on the function and energy transfer capability of fluorescent protein pairs

J. Pope, R. Johnson, W. D. Jamieson, H. Worthy, S. Kailasam, H. Auhim, D. Watkins, P. Rizkallah, O. Castell, D. Jones

This study shows that dimerization of fluorescent protein pairs alters their fluorescent properties and FRET efficiency, challenging assumptions about FP-based proximity sensing.

bioRxiv · Nov 12, 2019 · PreprintBiochemistry

Genomic and transcriptomic determinants of therapy resistance and immune landscape evolution during anti-EGFR treatment in colorectal cancer

A. Woolston, K. Khan, G. Spain, L. J. Barber, B. Griffiths, R. Gonzalez Exposito, Y. Patil, S. Mansukhani, M. N. Davies, A. Furness, F. Sclafani, C. Peckitt, K. Kouvelakis, R. Ranftl, R. Begum, , M. Gerlinger

The paper analyzes genomic and transcriptomic data from CRC patients treated with cetuximab to identify resistance mechanisms and immune landscape changes during anti-EGFR therapy.

bioRxiv · Oct 19, 2018Cancer Biology

Dynamic action of the Sec machinery during initiation, protein translocation and termination revealed by single molecule fluorescence

T. Fessl, D. Watkins, P. Oatley, W. J. Allen, R. A. Corey, J. Horne, S. A. Baldwin, S. E. Radford, I. Collinson, R. Tuma

This study uses single molecule FRET to analyze Sec machinery dynamics during protein translocation, revealing initiation, transport, and termination phases with specific roles for SecA and ATP hydrolysis.

bioRxiv · Jan 17, 2018Biophysics