RNase H1 counteracts DNA damage and ameliorates SMN-dependent phenotypes in a Drosophila model of Spinal Muscular Atrophy
Livia Scatolini, Lucia Graziadio, Damiano Guerrini, Paolo Maccallini, Carmen Marino, Raffaella di Vito, Amber Hassan, Manuela Grimaldi, Marco Fidaleo, Roozbeh Dehghannasiri, Gabriele Proietti, Roberto Piergentili, Erica Salvati, Stefano Cacchione, Cristiano De Pittà, , Grazia Daniela Raffa
This study shows that RNase H1 reduces DNA damage and improves SMA-like symptoms in a Drosophila model by resolving RNA:DNA hybrids caused by SMN deficiency.
bioRxiv · Apr 17, 2025 · PreprintGenetics