Paolo Maccallini

This study shows that RNase H1 reduces DNA damage and improves SMA-like symptoms in a Drosophila model by resolving RNA:DNA hybrids caused by SMN deficiency.

This study identifies a disease module for ME/CFS using network-based gene prioritization, highlighting metabolic pathways and potential genetic contributors.

This study shows TGS1 is essential for snRNA 3' end processing and its loss causes neurodegeneration, which can be mitigated by human TGS1 expression in model organisms.

This study identifies functional interactions between TGS1 and the Smn complex in Drosophila eye development, showing their roles in retinal progenitor cell viability and eye size.