Author

Gabriele Proietti

Italian Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Biochemistry· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:Drosophila· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:protein structure prediction· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Alessio ColantoniiD· 3 shared Gian Gaetano TartagliaiD· 3 shared Cristiano De PittàiD· 2 shared Giorgio Bini· 2 shared Grazia Daniela RaffaiD· 2 shared Livia Scatolini· 2 shared Lü CheniD· 2 shared Maurizio GattiiD· 2 shared

Activity by Year

2020-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersGenetics

Alessio ColantoniORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Leveraging Large-Scale Biobanks for Therapeutic Target Discovery

Brian R. Ferolito, Hesam Dashti, Claudia Giambartolomei, Gina Marie Peloso, Daniel J Golden, Kai Gravel-Pucillo, Danielle Rasooly, Andréa R. V. R. Horimoto, Rachael Matty, Liam Gaziano, Yi Liu, Ines A. Smit, Barbara Zdrazil, Yakov A. Tsepilov, Lauren Costa, , Alexandre C. Pereira

This study uses large biobanks to identify gene-trait pairs with causal evidence, rediscover approved drug targets, and develop a predictive model for drug development.

Human Genetics and Genomics Advances · Dec 10, 2025Peer-reviewedGenetic & Genomic Medicine

RNase H1 counteracts DNA damage and ameliorates SMN-dependent phenotypes in a Drosophila model of Spinal Muscular Atrophy

Livia Scatolini, Lucia Graziadio, Damiano Guerrini, Paolo Maccallini, Carmen Marino, Raffaella di Vito, Amber Hassan, Manuela Grimaldi, Marco Fidaleo, Roozbeh Dehghannasiri, Gabriele Proietti, Roberto Piergentili, Erica Salvati, Stefano Cacchione, Cristiano De Pittà, , Grazia Daniela Raffa

This study shows that RNase H1 reduces DNA damage and improves SMA-like symptoms in a Drosophila model by resolving RNA:DNA hybrids caused by SMN deficiency.

bioRxiv · Apr 17, 2025 · PreprintGenetics

Decoding RNA-RNA Interactions: The Role of Low-Complexity Repeats and a Deep Learning Framework for Sequence-Based Prediction

Adriano Setti, Giorgio Bini, Flaminia Pellegrini, Valentino Maiorca, Gabriele Proietti, Dimitrios Miltiadis Vrachnos, Angelo D’Angelo, Alexandros Armaos, Julie Martone, Michele M. Monti, Giancarlo Ruocco, Emanuele Rodolà, Irene Bozzoni, Alessio Colantoni, Gian Gaetano Tartaglia

This paper identifies low-complexity repeats as key drivers of RNA-RNA interactions and introduces RIME, a deep learning model that outperforms traditional methods in predicting these interactions.

bioRxiv · Feb 16, 2025 · PreprintBiochemistry

TGS1 controls snRNA 3' end processing, prevents neurodegeneration and ameliorates SMN-dependent neurological phenotypes in vivo

Lü Chen, Caitlin M. Roake, Paolo Maccallini, Francesca Bavasso, Roozbeh Dehghannasiri, Pamela Santonicola, Natalia Mendoza-Ferreira, Livia Scatolini, Ludovico Rizzuti, Alessandro Esposito, Ivan Gallotta, Sofia Francia, Stefano Cacchione, Alessandra Galati, Valeria Palumbo, , Grazia Daniela Raffa

This study shows TGS1 is essential for snRNA 3' end processing and its loss causes neurodegeneration, which can be mitigated by human TGS1 expression in model organisms.

bioRxiv · Oct 27, 2020 · PreprintGenetics