Allosteric binders of ACE2 are promising anti-SARS-CoV-2 agents
Joshua E. Hochuli, Sankalp Jain, Cleber Camilo Melo-Filho, Zoe L. Sessions, Tesia Bobrowski, Jun Choe, Johnny Zheng, Richard T. Eastman, Daniel C. Talley, Ganesha Rai, Anton M. Simeonov, Alexander Tropsha, Eugene N. Muratov, Bolormaa Baljinnyam, Alexey V. Zakharov
The paper identifies five compounds that inhibit SARS-CoV-2 replication by binding to ACE2 without disrupting its enzymatic function, serving as potential acute treatments for COVID-19.
ACS Pharmacology & Translational Science · Jun 22, 2022Peer-reviewedBioinformatics