The CoREST complex inhibitor, corin, leads to decreased tumor growth, increased cellular differentiation and extended lifespan in atypical teratoid rhabdoid tumor xenograft models
Anupa Geethadevi, Nikhil Vaidya, Robert J. Fisher, Tyler Findlay, Yiming Deng, Khoa Pham, Vikas Kumar, Samuel Beck, Jun Choe, Shiyu Liu, Calixto-Hope G. Lucas, Charles G. Eberhart, Jinchong Xu, Philip A Cole, Jeffrey A. Rubens, , Rhoda M. Alani
This study shows that corin, a CoREST inhibitor, reduces ATRT tumor growth, increases differentiation, and extends lifespan in xenograft models.
Neuro-Oncology · Jul 21, 2026Peer-reviewedCancer Biology