Bloom syndrome helicase is required for efficient HIV-1 reverse transcription in macrophages
Andrew A. Leal, Samantha Tafrate, Xianbao He, Daniel L. Bryant, Melissa Beth Herring, Maria Andrade, Joseph B McWhirter, Andrés A. Quiñones-Molina, Suryaram Gummuluru, Manish Sagar, Rachel Litman Flynn, Ignaty Leshchiner, Andrew J. Henderson
This study identifies Bloom syndrome helicase (BLM) as a host factor that promotes HIV-1 reverse transcription and integration in macrophages through CRISPR screening and functional assays.
bioRxiv · Apr 27, 2026 · PreprintMicrobiology