Xianbao He

This study identifies Bloom syndrome helicase (BLM) as a host factor that promotes HIV-1 reverse transcription and integration in macrophages through CRISPR screening and functional assays.

This study shows that MDA5 senses HIV-1 unspliced RNA based on 5' cap structure and nuclear export pathway, revealing how the virus evades innate immunity.

The paper finds that recent endemic coronavirus infection is associated with higher SARS-CoV-2 cross-reactive Fc receptor binding antibodies, which may contribute to reduced severe COVID-19.