Molecular glues that inhibit deubiquitylase activity and inflammatory signalling
Francesca Chandler, Poli Adi Narayana Reddy, Smita Bhutda, Rebecca L. Ross, Arindam Datta, Miriam Walden, Kieran Walker, Stefano Di Donato, Joel A. Cassel, Michael A. Prakesch, Ahmed M. Aman, Alessandro Datti, Lisa J. Campbell, Martina Foglizzo, Lillie Bell, , Elton Zeqiraj
The paper identifies first-in-class inhibitors (BLUEs) that selectively inhibit BRISC complex activity by stabilizing an autoinhibited dimer, reducing interferon-stimulated gene expression.
Nature Structural & Molecular Biology · Mar 17, 2025Peer-reviewedBiochemistry