Targeting Tenascin-C-Toll-like Receptor 4 signalling with Adhiron-derived small molecules - a viable strategy for reducing fibrosis in Systemic Sclerosis
Thembaninkosi G. Gaule, Katie J. Simmons, Kieran Walker, Francesco Del Galdo, Rebecca L. Ross, Hema Viswambharan, Jahnavi Krishnappa, Jack Pacey, Martin J. McPhillie, Darren Charles Tomlinson, Azhar Maqbool
This paper identifies small molecules targeting the Tenascin C fibrinogen-like globe domain to reduce fibrosis in systemic sclerosis by inhibiting Toll-like receptor 4 signaling.
Bioorganic Chemistry · Nov 20, 2025Peer-reviewedPhysiology