Frank Sicheri

Mitotic single-stranded DNA suppression by DDIAS

The paper identifies DDIAS as a DNA-binding effector of the CIP2A-TOPBP1 complex that suppresses single-stranded DNA during mitosis, protecting genome integrity and interacting genetically with DNA polymerase.

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture

The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.

Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry

This paper identifies how Bora activates Aurora A and Plk1 kinases during mitosis through structural and biochemical analysis.

WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response

This study shows WEE1 inhibitors trigger the integrated stress response via GCN2 activation, leading to translational shutdown, which can be mitigated by low-dose or combination treatments.

Molecular glues that inhibit deubiquitylase activity and inflammatory signalling

The paper identifies first-in-class inhibitors (BLUEs) that selectively inhibit BRISC complex activity by stabilizing an autoinhibited dimer, reducing interferon-stimulated gene expression.

ProteoSync, a program for ortholog selection, automated sequence alignment and conservation projection onto protein atomic coordinates