Joel A. Cassel

This study shows lamin A/C maintains genome structure and transcriptional programs needed for EBV-driven B cell activation, with loss causing chromatin reorganization and gene expression changes.

This paper identifies Siglec-10/α3β1 integrin interactions as a mechanism suppressing macrophage phagocytosis in PDAC and shows that targeting these interactions enhances anti-tumor immunity.

This study shows targeting the LxCxE cleft pocket of Rb in M2 macrophages inhibits ovarian cancer progression by reducing immunosuppressive TAMs and enhancing T cell infiltration.

The paper identifies first-in-class inhibitors (BLUEs) that selectively inhibit BRISC complex activity by stabilizing an autoinhibited dimer, reducing interferon-stimulated gene expression.

This paper introduces a microplate reader-based method to detect HIV latency reversal in J-Lat cells without flow cytometry, identifying new latency-reversing agents.

This study identifies SLC25A1-mediated citrate transport as a mechanism protecting pancreatic cancer cells from ferroptosis under nutrient stress, with therapeutic implications for PDAC.

The paper isolates and characterizes neutralizing anti-interferon-alpha and anti-interferon-beta antibodies from human patients, showing their specificity and potential therapeutic applications.