Castling, a novel therapeutic concept for rewiring pathological gene-expression networks, enabled by the TRIPLE technology
Dinu Antony, Maria Silvia Roman Azcona, Hagar Kalinski, Marianne Pultar, Swetlana Adamsky, Sharon Avkin Nachum, Eyal Shalom, Manuel Rhiel, Andreas Tsouris, Andreas B. Diendorfer, Geoffroy Andrieux, Melanie Boerries, Matthias Hackl, Tatjana I. Cornu, Daniel Zurr, , Claudio Mussolino
The paper introduces a therapeutic strategy called castling to correct gene-expression imbalances by rewiring miRNA regulation using the TRIPLE genome-editing technology.
bioRxiv · Feb 19, 2026 · PreprintMolecular Biology