This study shows that metabolic reprogramming of human macrophages using DASA-58 generates hybrid M1/M2 extracellular vesicles with pro-regenerative properties that enhance angiogenesis and osteogenesis.

Biomaterials · Apr 15, 2026Peer-reviewedImmunology

Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles

Alessia Brancolini, Madhusudhan Reddy Bobbili, Marianne Pultar, Zahra Mazidi, Matthias Wieser, Johanna Gamauf, Marieke Theodora Roefs, Giulia Corso, Harini Nivarthi, Maria Belen Arteaga, Dieter Bettelheim, Elsa Arcalís, Dmitry Sivun, Jaroslaw Jacak, Iris Gerner, , Regina Grillari‐Voglauer

Journal of Biotechnology · Mar 12, 2026Peer-reviewedCell Biology

Castling, a novel therapeutic concept for rewiring pathological gene-expression networks, enabled by the TRIPLE technology

Dinu Antony, Maria Silvia Roman Azcona, Hagar Kalinski, Marianne Pultar, Swetlana Adamsky, Sharon Avkin Nachum, Eyal Shalom, Manuel Rhiel, Andreas Tsouris, Andreas B. Diendorfer, Geoffroy Andrieux, Melanie Boerries, Matthias Hackl, Tatjana I. Cornu, Daniel Zurr, , Claudio Mussolino

The paper introduces a therapeutic strategy called castling to correct gene-expression imbalances by rewiring miRNA regulation using the TRIPLE genome-editing technology.

bioRxiv · Feb 19, 2026 · PreprintMolecular Biology

Profiling microRNA expression during senescence and aging: mining for a diagnostic tool of senescent-cell burden

Moritz Weigl, Teresa L. Krammer, Marianne Pultar, Matthias Wieser, Selim Chaib, Masayoshi Suda, Andreas B. Diendorfer, Kseniya Khamina, Nino Giorgadze, Tamar Pirtskhalava, Kurt O. Johnson, Christina L. Inman, Ailing Xue, Ingo Lämmermann, Barbara Meixner, , Johannes Grillari

The paper profiles miRNA expression during senescence and aging to identify potential circulating biomarkers of senescent cell burden in mice and humans.

bioRxiv · Apr 10, 2024 · PreprintMolecular Biology

Small non-coding RNA landscape of extracellular vesicles from a post-traumatic model of equine osteoarthritis

James Ross Anderson, Stine Engesgaard Jacobsen, Marie Walters, Louise Bundgaard, Andreas B. Diendorfer, Matthias Hackl, Emily J. Clarke, Victoria H. James, Mandy Jayne Peffers

The paper identifies small non-coding RNA biomarkers in extracellular vesicles from equine osteoarthritis models using small RNA sequencing and bioinformatics analysis.

Frontiers in Veterinary Science · Aug 8, 2022Peer-reviewedMolecular Biology

SVF-derived extracellular vesicles carry characteristic miRNAs in lipedema

Eleni Priglinger, Karin Strohmeier, Moritz Weigl, Carolin Lindner, Daniela Auer, Mario Gimona, Martin Barsch, Jaroslaw Jacak, Heinz R. Redl, Johannes Grillari, Matthias Sandhofer, Matthias Hackl, Susanne Wolbank

This study compares extracellular miRNA profiles in lipedema and healthy adipose tissue, finding that sEV miRNAs are differentially regulated in lipedema.

Scientific Reports · Apr 29, 2020Peer-reviewedMolecular Biology

MiR-146a controls age related bone loss

Victoria Saferding, Melanie Hofmann, Julia S. Brunner, Birgit Niederreiter, Melanie Timmen, Nathaniel Magilnick, Silvia Hayer, Gerwin Heller, G.E. Steiner, Richard Stange, Mark Boldin, Gernot Schabbauer, Moritz Weigl, Matthias Hackl, Johannes Grillari, , Stephan Blüml

This study identifies miR-146a as a key regulator of age-related bone loss, showing its role in controlling bone homeostasis through Wnt signaling and its potential as a therapeutic target.

bioRxiv · Mar 20, 2020 · PreprintMolecular Biology

MicroRNA levels in bone and blood change during bisphosphonate and teriparatide therapy in an animal model of postmenopausal osteoporosis

Roland Kocijan, Moritz Weigl, Susanna Skalicky, Elisabeth Geiger, James Ferguson, Gabriele Leinfellner, Patrick Heimel, Peter Pietschmann, Johannes Grillari, Heinz R. Redl, Matthias Hackl

This study examines miRNA changes in bone and blood during bisphosphonate and teriparatide treatment in an osteoporosis animal model, finding significant miRNA regulation linked to bone remodeling.

Bone · Nov 3, 2019Peer-reviewedMolecular Biology