Unraveling cysteine deficiency-associated rapid weight loss
Alan Varghese, Ivan Gusarov, Begona Gamallo‐Lana, Daria Dolgonos, Yatin Mankan, Ilya Shamovsky, Mydia Phan, Rebecca Jones, Maria Gomez-Jenkins, Eileen White, Rui Wang, Drew R. Jones, Thales Y. Papagiannakopoulos, Michael E. Pacold, Adam C. Mar, , Evgeny Nudler
This study shows that cysteine restriction in mice causes rapid weight loss by depleting glutathione and coenzyme A, activating stress responses, and increasing lipolysis.
Nature · May 21, 2025Peer-reviewedPhysiology