A fluorescent folding reporter uncovers myosin misfolding as a driver of Hypertrophic Cardiomyopathy
Renato Arnese, Philipp J. Dexheimer, Beatriz Escobar-Doncel, Lotta Krüger, Govinda Adhikari, Nina Krpan, Daria Sehr, Juliane Kley, Luiza Deszcz, Anton Meinhart, Janine Kirstein, Tim Clausen
This study identifies myosin misfolding as a driver of HCM using a fluorescent reporter and C. elegans model, showing dietary restrictions can reverse defects via autophagy.
bioRxiv · Feb 10, 2025 · PreprintCell Biology