Author

Luiza Deszcz

Research Institute of Molecular PathologyORCID 0000-0001-5004-3584Unclaimed ORCID profile · follow to get notified of new preprints

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Luiza Deszcz1 paper

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Anton MeinhartiD· 2 shared Tim ClauseniD· 2 shared Alexander SchleifferiD· 1 shared Alexandra ShulkinaiD· 1 shared Beatriz Escobar-DonceliD· 1 shared Daniel B. GrabarczykiD· 1 shared Daria Sehr· 1 shared Eszter ZavodszkyiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Anton MeinhartORCID

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2 papers

Recent·Most cited

BiochemistrySciencePeer-reviewedAug 28, 2025

Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control

Daniel B. Grabarczyk, Julian F. Ehrmann, Paul V. Murphy…·Tim Clausen

The paper presents the cryo-EM structure of the UBR4 complex, revealing its architecture and mechanism for substrate binding and ubiquitin chain extension in protein quality control.

20 citationstop 3%

experimental assayprotein folding & dynamics

𝕏 PostBluesky

Cell BiologybioRxivPreprintFeb 10, 2025

A fluorescent folding reporter uncovers myosin misfolding as a driver of Hypertrophic Cardiomyopathy

Renato Arnese, Philipp J. Dexheimer, Beatriz Escobar-Doncel…·Tim Clausen

This study identifies myosin misfolding as a driver of HCM using a fluorescent reporter and C. elegans model, showing dietary restrictions can reverse defects via autophagy.

DOI 10.1101/2025.02.10.636595

C. elegansexperimental assay

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