Author

Elyse M. Petrunak

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Alison LeediD· 1 shared Andrew P. LiebermaniD· 1 shared Andriy O. SamokhiniD· 1 shared Anna Szczeniowski· 1 shared Behnoush Hajian· 1 shared Bradley A. MaroniD· 1 shared David B. LombardiD· 1 shared David C. McKinneyiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Alison LeedORCID

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2 papers

Recent·Most cited

Targeting NEDD9-SH3 with a Covalent Peptide Controls Endothelial Phenotype

Andriy O. Samokhin, Hyuk‐Soo Seo, Alison Leed, Behnoush Hajian, Gregory H. Bird, David C. McKinney, Progyaparamita Saha, Jacqueline Daum, Jamie A. Moroco, Jenna Yehl, David J. P. Kornfilt, Anna Szczeniowski, Elyse M. Petrunak, Steven L. Horner, Jay H. Kalin, , Bradley A. Maron

This study develops a covalent peptide targeting NEDD9-SH3 to inhibit endothelial migration and fibroproliferative remodeling in PAH by stabilizing the RT loop and modulating sulfatase-1 activity.

bioRxiv · Jul 10, 2025 · PreprintMolecular Biology

SIRT5 variants from patients with mitochondrial disease are associated with reduced SIRT5 stability and activity, but not with neuropathology

Taolin Yuan, Surinder Kumar, Mary E. Skinner, Ryan Victor-Joseph, Majd Abuaita, Jaap Keijer, Jessica Zhang, Thaddeus J. Kunkel, Yanghan Liu, Elyse M. Petrunak, Thomas L. Saunders, Andrew P. Lieberman, Jeanne A. Stuckey, Nouri Neamati, Fathiya M. Al-Murshedi, , David B. Lombard

The paper identifies two SIRT5 variants in mitochondrial disease patients that reduce protein stability and activity but not neuropathology, using biochemical and mouse model analyses.

bioRxiv · Dec 6, 2023 · PreprintGenetics