Author

David D Ho

Aaron Diamond AIDS Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Organism:rat· 1

Frequent Co-Authors

Jian YuiD· 2 shared Afam A. OkoyeiD· 1 shared Alejandra Marenco· 1 shared Anthony Bowen· 1 shared Baoshan ZhangiD· 1 shared Benjamin D. Varco-Merth· 1 shared Bo HuiD· 1 shared Harry Baffour Awuah· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

Jian YuORCID

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2 papers

Recent·Most cited

A Bispecific Biologic That Robustly Reverses HIV-1 and SIV Latency

Yaoxing Huang, Manoj S. Nair, Jian Yu, Sue Chong, Hsiang Hong, Hiroshi Mohri, Hiroshi Takata, Benjamin D. Varco-Merth, Alejandra Marenco, Jeffrey D. Lifson, Lishomwa C. Ndhlovu, Anthony Bowen, Lydie Trautmann, Sandhya Vasan, Tae‐Wook Chun, , David D Ho

This paper develops a bispecific biologic that effectively reactivates HIV-1 and SIV latency in multiple models with minimal off-target effects.

bioRxiv · Oct 8, 2026 · PreprintMicrobiology

Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization

Wang Xu, Narendra Kumar Gonepudi, Junyu Liu, Yufan He, Revansiddha H. Katte, Ran Wang, Harry Baffour Awuah, Yang Han, Baoshan Zhang, Jian Yu, Bo Hu, David D Ho, Priyamvada Acharya, Peter D. Kwong, Maolin Lu

This study uses single-molecule FRET to show that gp41-directed antibodies stabilize or open the prefusion-closed state of HIV-1 Env, revealing two neutralization mechanisms.

bioRxiv · Aug 12, 2026Microbiology