Lishomwa C. Ndhlovu

This paper develops a bispecific biologic that effectively reactivates HIV-1 and SIV latency in multiple models with minimal off-target effects.

This study shows that inhibiting glycan degradation prevents HIV-induced inflammation, aging, and cognitive impairment in animal models and human cohorts.

This study shows CBD reduces viral replication and immune activation in HIV/SIV models, suggesting it could be a useful adjunct to antiretroviral therapy.

This study shows that Staphylococcus aureus translocation promotes anti-CD4 autoantibodies in HIV patients on ART, impairing CD4+ T cell recovery.

Direct reprogramming of skin fibroblasts into neurons reveals unique gene signatures indicative of HIV infection in the context of viral suppression.

The paper uses scRNA-seq to show that monocyte IL1B expression inversely correlates with HIV-1 reservoir size in ART-treated individuals.

This study constructs epigenetic clocks using retroelement DNA methylation states to predict chronological age across human tissues and species, showing their reversibility and responsiveness to HIV treatment.

The paper introduces ScISOr-ATAC to measure splicing and chromatin accessibility in frozen brain tissues, finding convergent and divergent patterns in different cell types and conditions.

The paper analyzes single-cell long-read mRNA isoform regulation across mouse brain regions, cell types, and development, finding pervasive isoform variability and cell-type specific splicing patterns.

The paper introduces SnISOr-Seq, a method for single-nuclei isoform RNA sequencing, and finds distinct combination patterns of transcript elements in human brain cell types.