Author

Vinitha Jacob

University of MichiganORCID 0000-0002-3786-1520Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:zebrafish· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Stefan H. OehlersiD· 2 shared Xiangyu Sui· 2 shared Andrew H. Bertrand· 1 shared Annelore Fleischmann· 1 shared Beulah Augustin· 1 shared Charlotte HopsoniD· 1 shared Darryl JY HaniD· 1 shared David M Costa· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

Stefan H. OehlersORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Deciphering sepsis molecular subtypes using large-scale data to identify subtype-specific drug repurposing

Leslie Arthur Smith, Beulah Augustin, Vinitha Jacob, Lauren Page Black, Andrew H. Bertrand, Charlotte Hopson, Emilio B. Cagmat, Susmita Datta, Srinivasa T. Reddy, Faheem W. Guirgis, Kiley S. Graim

This paper identifies four molecular subtypes of sepsis using transcriptomic data and proposes subtype-specific drug repurposing opportunities, including potential therapies for high mortality subtypes.

bioRxiv · Sep 28, 2026 · PreprintBioinformatics

Loss of 7-Dehydrocholesterol Reductase-mediated cholesterol biosynthesis activates IRF3 and inhibits control of Mycobacterium marinum infection

Xiangyu Sui, Darryl JY Han, David M Costa, Vinitha Jacob, Stefan H. Oehlers

This study shows that loss of DHCR7 leads to increased 7DHC, which activates IRF3 and impairs anti-bacterial immunity against Mycobacterium marinum in zebrafish.

bioRxiv · May 12, 2026 · PreprintImmunology

Dabigatran prevents lipopolysaccharide mediated apoptosis in zebrafish through a thrombin independent mechanism

Annelore Fleischmann, William Woodhams, Ritta Mouayed, Timmy Joseph, Xiangyu Sui, Murat Yaman, Stefan H. Oehlers, Jordan A. Shavit, Vinitha Jacob

This study identifies novel small molecules that prevent LPS-induced endotoxemia in zebrafish, showing that dabigatran protects through a thrombin-independent mechanism.

Shock · Jan 28, 2026Peer-reviewedPharmacology & Toxicology