Aging disrupts cumulus-oocyte NAD homeostasis
Bettina P. Mihalas, De Lin, Sonia Bustamante, Russell Pickford, Emily R. Frost, Ananya Vuyyuru, Derek Y.H. Wong, Michael J. Bertoldo, Lindsay E. Wu, Robert Bruce Gilchrist
This study identifies age-related disruption in cumulus-oocyte NAD homeostasis through metabolic coupling, showing that NMN supplementation improves oocyte redox status in aged mice.
bioRxiv · Jul 23, 2026 · PreprintCell Biology