De Lin

Mechanistic Insights into Dual-Active Liver and Blood-Stage Antiplasmodials

This paper identifies targets of dual-active antimalarials by evolving resistance to nine compounds and validates them using CRISPR and molecular docking.

Spatially Resolved Determination of Small Molecule Protein Affinities by Hydrogen Deuterium Exchange Mass Spectrometry

This paper introduces an HDX-MS workflow to estimate dissociation constants for ligand-protein interactions at peptide and amino acid resolution, enabling spatially resolved affinity mapping.

Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach

This study characterizes small molecule inhibitors of the HsRNMT-RAM complex, showing competitive binding and uncompetitive inhibition of RNA cap methylation.

Identification of a novel false-positive mechanism in RapidFire mass spectrometry and application in drug discovery

The paper identifies a novel false-positive mechanism in RapidFire mass spectrometry and develops a pipeline to detect and mitigate these false positives in drug discovery.