Emily R. Frost

A proteomic signature of oocyte quality from models of varying oocyte developmental competence

This study identifies proteomic differences between in vivo and in vitro matured mouse oocytes, revealing dysregulated pathways in in vitro systems and conserved patterns in human oocytes.

Aging disrupts cumulus-oocyte NAD homeostasis

This study identifies age-related disruption in cumulus-oocyte NAD homeostasis through metabolic coupling, showing that NMN supplementation improves oocyte redox status in aged mice.

Roles of TYRO3 Family Receptors in Germ Cell Development During Mouse Testis Formation

This study investigates the role of TAM family receptors in mouse testis development, finding that their inhibition reduces germ cell numbers and that Tyro3 knockout affects gene expression in germ and Sertoli cells.

Pregranulosa cells engage a distinct transcriptional programme prior to cell-cycle dependent primordial follicle activation

The paper identifies a distinct transcriptional programme in pregranulosa cells before primordial follicle activation using single-cell RNA sequencing in mice.