Author

Bettina P. Mihalas

UNSW SydneyORCID 0000-0002-6006-8475Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:imaging· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Ananya VuyyuruiD· 2 shared Emily R. FrostiD· 2 shared Lindsay E. WuiD· 2 shared Robert Bruce GilchristiD· 2 shared Adèle L. MarstoniD· 1 shared Andrew D. McAinshiD· 1 shared Anne PoljakiD· 1 shared Cerys E. CurrieiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

Ananya VuyyuruORCID

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3 papers

Recent·Most cited

A proteomic signature of oocyte quality from models of varying oocyte developmental competence

Emily R. Frost, Dulama Richani, Anne Poljak, Ananya Vuyyuru, Xuihua Liao, Elise Georgiou, J M Binuri Gunasekara, Bettina P. Mihalas, Irene E Sucquart, Kaushiki M. Kadam, Lindsay E. Wu, Robert Bruce Gilchrist

This study identifies proteomic differences between in vivo and in vitro matured mouse oocytes, revealing dysregulated pathways in in vitro systems and conserved patterns in human oocytes.

Human Reproduction · Aug 5, 2026Peer-reviewedCell Biology

Aging disrupts cumulus-oocyte NAD homeostasis

Bettina P. Mihalas, De Lin, Sonia Bustamante, Russell Pickford, Emily R. Frost, Ananya Vuyyuru, Derek Y.H. Wong, Michael J. Bertoldo, Lindsay E. Wu, Robert Bruce Gilchrist

This study identifies age-related disruption in cumulus-oocyte NAD homeostasis through metabolic coupling, showing that NMN supplementation improves oocyte redox status in aged mice.

bioRxiv · Jul 23, 2026 · PreprintCell Biology

Multi-nucleation in two-cell human embryos stems from spindle and metaphase plate incoherence in the first mitosis

Gerard H. Pieper, Mansour Aboelenain, Lucy Munro, Bettina P. Mihalas, Cerys E. Currie, Deborah M. Taylor, Daniel M. Collins, Geraldine M. Hartshorne, Andrew D. McAinsh, Richard A. Anderson, Adèle L. Marston

The paper investigates the causes of multi-nucleation in two-cell human embryos and finds that spindle and metaphase plate incoherence during the first mitosis leads to this phenomenon.

bioRxiv · Aug 20, 2025 · PreprintCell Biology