Discovery of stereoselective targeted covalent inhibitors of the RAB27-effector protein-protein interaction
Elena De Vita, Adam Thomas, Delia Brustur, Montse Tersa, Rita Petracca, Shradda Vadodaria, Deborah A. Briggs, Jack W. Houghton, Thomas Lanyon‐Hogg, Gregory B. Craven, Rhodri M. L. Morgan, Alan Armstrong, David J. Mann, Katharine M. Lodge, Alistair N. Hume, , Edward W. Tate
This paper develops the first cell-active covalent inhibitors of RAB27-effector interactions, showing enantioselectivity and improved potency over a previously reported toxic compound.
Journal of the American Chemical Society · Aug 3, 2026Peer-reviewedBiochemistry