Author

Patrick Zheng

National Institutes of Health

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Genetics· 1

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Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Achim A WerneriD· 1 shared Amy K. WangiD· 1 shared Brecca MilleriD· 1 shared Dan Avi LandauiD· 1 shared David B. BeckiD· 1 shared Deborah Rivera· 1 shared Duy T. TraniD· 1 shared Iannis AifantisiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperGenetics

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1 paper

Recent·Most cited

Cell autonomous inflammation in VEXAS is mediated by cGAS-STING

Samuel J. Magaziner, Jason C. Collins, Brecca Miller, Patrick Zheng, Amy K. Wang, Jérôme Hadjadj, Juan Carlos Balandrán, Maria Sirenko, Maya English, James Bertlin, Rebecca L. Murray, Peter H. Whitney, Tania J González-Robles, Deborah Rivera, Yan Wang, , David B. Beck

This study identifies cGAS-STING pathway activation as a key mechanism of inflammation in VEXAS, showing that UBA1 mutations disrupt ERAD and mitochondrial homeostasis, leading to STING-driven inflammation.

bioRxiv · May 29, 2026 · PreprintGenetics