Peter H. Whitney

ZATELLITE enables real-time visualization and manipulation of human centromeres in live cells using synthetic zinc fingers without causing DNA damage.

This study identifies cGAS-STING pathway activation as a key mechanism of inflammation in VEXAS, showing that UBA1 mutations disrupt ERAD and mitochondrial homeostasis, leading to STING-driven inflammation.

BeadBuddy corrects chromatic errors in single-molecule imaging data using fluorescent bead images, achieving sub-voxel resolution in DNA FISH and applicable across SMLM modalities.

The paper measures transcriptional kinetics at the sog locus in Drosophila to show that shadow enhancers integrate activation and repression signals differently, leading to distinct patterning outcomes.

The paper shows that active genes in Drosophila embryos are not spatially clustered but instead have distinct Pol II pools, supporting an 'individualist' model over a 'collectivist' model of gene regulation.

The paper investigates how the Drosophila pioneer factor Zelda enhances transcriptional output of the Dorsal target gene sog by modulating the nuclear microenvironment and increasing Dorsal accumulation at the enhancer.