Jonathon P. Sens

Granulocyte colony-stimulating factor acts through calcium-permeable AMPA receptors to potentiate cocaine reward

This study shows that G-CSF enhances cocaine reward by promoting glutamatergic synaptic remodeling in the nucleus accumbens through calcium-permeable AMPA receptors.

Synchrony between midbrain gene transcription and dopamine terminal regulation is modulated by chronic alcohol drinking

The paper examines how chronic alcohol drinking affects the relationship between gene expression and dopamine regulation in the brain, finding persistent functional changes despite no change in transcript levels.

Brief disruption of the microbiome has age-dependent effects on morphine reward and gene expression in the medial prefrontal cortex of adolescent and adult mice

This study shows that disrupting the microbiome affects morphine reward and gene expression in the medial prefrontal cortex differently in adolescent and adult mice.

Synaptogyrin-3 Prevents Cocaine Addiction and Dopamine Deficits

This study shows that synaptogyrin-3 reduces cocaine self-administration and prevents dopamine deficits by enhancing dopamine signaling and cognitive flexibility in rats.

Microbial short-chain fatty acids regulate drug seeking and transcriptional control in a model of cocaine seeking

This study shows that gut microbiome depletion increases cocaine-seeking behavior in rats, which can be reversed by replenishing short-chain fatty acids.

Systematic analysis of dark and camouflaged genes: disease-relevant genes hiding in plain sight

The paper identifies dark and camouflaged gene regions in the human genome, shows how long-read sequencing reduces their prevalence, and applies an algorithm to uncover disease-relevant variants in Alzheimer's Disease Sequencing Project data.

Long-read sequencing across the C9orf72 ‘GGGGCC’ repeat expansion: implications for clinical use and genetic discovery efforts in human disease

This study demonstrates that long-read sequencing can characterize the C9orf72 G4C2 repeat expansion in disease carriers, showing potential for clinical and genetic discovery applications.