Author

Dmitry I. Zhigarev

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Dmitry I. ZhigareviD2 papers · Fox Chase Cancer Center

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Assay:clinical cohort / trial· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Adi Narayana Reddy PoliiD· 1 shared Andres J. Klein–SzantoiD· 1 shared Andrew V. KossenkoviD· 1 shared Ariana Musa de AquinoiD· 1 shared Avishek BhuniyaiD· 1 shared Bryan BristowiD· 1 shared Charline OgieriD· 1 shared Colin HartiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Adi Narayana Reddy PoliORCID

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2 papers

Recent·Most cited

Targeting LxCxE cleft pocket of retinoblastoma protein in M2 macrophages inhibits ovarian cancer progression

Evgenii N. Tcyganov, Taekyoung Kwak, Xue Yang, Adi Narayana Reddy Poli, Colin Hart, Avishek Bhuniya, Joel A. Cassel, Andrew V. Kossenkov, Noam Auslander, Lily Sia Lu, Paridhima Sharma, Maria De Grecia Cauti Mendoza, Dmitry I. Zhigarev, Gwendolyn M. Cramer, Mark Gregory Cadungog, , Luis J. Montaner

This study shows targeting the LxCxE cleft pocket of Rb in M2 macrophages inhibits ovarian cancer progression by reducing immunosuppressive TAMs and enhancing T cell infiltration.

Cancer Immunology Research · Sep 9, 2025Peer-reviewedImmunology

Netrin G1 Ligand is a new stromal immunomodulator that promotes pancreatic cancer

Debora Barbosa Vendramini Costa, Ralph Francescone, Janusz Franco‐Barraza, Tiffany Luong, Myree Graves, Ariana Musa de Aquino, Nina G. Steele, Jaye C. Gardiner, Sérgio Alexandre Alcântara dos Santos, Charline Ogier, Emily Malloy, Leila Borghaei, Esteban Martı́nez, Dmitry I. Zhigarev, Yinfei Tan, , Edna Cukierman

This paper identifies NGL-1 as a stromal immunomodulator in pancreatic cancer that promotes tumor growth by modulating the tumor microenvironment through TGF-β and transcription factor pathways.

bioRxiv · May 15, 2024 · PreprintCancer Biology