Author

Paridhima Sharma

The Wistar InstituteORCID 0009-0004-8093-1063Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Luis J. MontaneriD· 2 shared Aaron R. GoldmaniD· 1 shared Adi Narayana Reddy PoliiD· 1 shared Andrew V. KossenkoviD· 1 shared Avishek BhuniyaiD· 1 shared Boingotlo RaphaneiD· 1 shared Brian N. Ross· 1 shared Bryan BristowiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Luis J. MontanerORCID

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2 papers

Recent·Most cited

Targeting LxCxE cleft pocket of retinoblastoma protein in M2 macrophages inhibits ovarian cancer progression

Evgenii N. Tcyganov, Taekyoung Kwak, Xue Yang, Adi Narayana Reddy Poli, Colin Hart, Avishek Bhuniya, Joel A. Cassel, Andrew V. Kossenkov, Noam Auslander, Lily Sia Lu, Paridhima Sharma, Maria De Grecia Cauti Mendoza, Dmitry I. Zhigarev, Gwendolyn M. Cramer, Mark Gregory Cadungog, , Luis J. Montaner

This study shows targeting the LxCxE cleft pocket of Rb in M2 macrophages inhibits ovarian cancer progression by reducing immunosuppressive TAMs and enhancing T cell infiltration.

Cancer Immunology Research · Sep 9, 2025Peer-reviewedImmunology

Ex vivo and in vivo HIV-1 latency reversal by Mukungulu, a protein kinase C-activating African medicinal plant extract

Khumoekae Richard, Zhe Yuan, Hsin‐Yao Tang, Aaron R. Goldman, Riza Kuthu, Boingotlo Raphane, Emery T. Register, Paridhima Sharma, Brian N. Ross, Jessicamarie Morris, David E. Williams, Carol A. Cheney, Guoxin Wu, Karam Mounzer, Gregory M. Laird, , Luis J. Montaner

This study shows that Mukungulu, an African medicinal plant extract, effectively reverses HIV-1 latency in humanized mice and human cells, outperforming standard controls.

mBio · Apr 23, 2025Peer-reviewedMicrobiology