Author

Ralph A. Francescone III

Henry Ford HealthORCID 0000-0002-3149-6825Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Debora Barbosa Vendramini CostaiD· 3 shared Edna CukiermaniD· 2 shared Ian M. LovelessiD· 2 shared Nina G. SteeleiD· 2 shared Adrianne Wallace-PovirkiD· 1 shared Afrooz Jarrah· 1 shared Aidan SchutteriD· 1 shared Albert M. LeviniD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

Debora Barbosa Vendramini CostaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

HMGA2 Expression in Pancreatic Ductal Adenocarcinoma Controls Tumor Microenvironment and Immunosuppression via IL1α

Naomi Yamamoto, Stephanie Dobersch, Tess M. Robertson, Jae Hyung Sim, Adrianne Wallace-Povirk, Nayvin W. Chew, Alexander E. Orellana, Joana E. Aggrey-Fynn, Liberalis Debraj Boila, Aidan Schutter, Ian M. Loveless, Gun Ho Jang, Shayan Avanessian, Gregory Lawrence Beatty, Suni R Hingorani, , Sita Kugel

This study shows HMGA2 in PDAC drives immunosuppressive TME by upregulating IL1α, which promotes CAFs and reduces CD8+ T cells, and blocking IL1 improves tumor control with KRAS inhibitors.

bioRxiv · Oct 6, 2026 · PreprintCancer Biology

Keloid transcriptomics reveal heterogeneity in fibroblast subtype enrichment, gene expression, and immune cell responses

Jonathan J. Panzer, Mingming Pan, Mrudula Nair, Ian M. Loveless, Xiangguo Dai, Indra Adrianto, Ling Huang, Dhananjay Arun Chitale, Ralph A. Francescone III, Debora Barbosa Vendramini Costa, Cristina de Guzman Strong, Albert M. Levin, Lamont R. Jones

The paper identifies cell type-specific gene expression and immune cell associations in keloid tissue using bulk RNA-Seq and single sample gene set enrichment analysis.

bioRxiv · Sep 7, 2026 · PreprintBioinformatics

Sensory neurons inhibit invadopodia and metastasis via direct CGRP-RAMP1-cAMP signaling to cancer cells

Ines Velazquez Quesada, Elizaveta Belova, Afrooz Jarrah, Maria Carolina Cesar Mariano, Yasmine Dahleh, Maíra A. Lima, Debora Barbosa Vendramini Costa, Ralph A. Francescone III, Edna Cukierman, Louis Hodgson, Bojana Gligorijevic

This study shows sensory neurons inhibit breast cancer metastasis via CGRP-RAMP1-cAMP signaling, which suppresses invadopodia and ECM degradation.

bioRxiv · Apr 21, 2026 · PreprintCancer Biology

Netrin G1 Ligand is a new stromal immunomodulator that promotes pancreatic cancer

Debora Barbosa Vendramini Costa, Ralph Francescone, Janusz Franco‐Barraza, Tiffany Luong, Myree Graves, Ariana Musa de Aquino, Nina G. Steele, Jaye C. Gardiner, Sérgio Alexandre Alcântara dos Santos, Charline Ogier, Emily Malloy, Leila Borghaei, Esteban Martı́nez, Dmitry I. Zhigarev, Yinfei Tan, , Edna Cukierman

This paper identifies NGL-1 as a stromal immunomodulator in pancreatic cancer that promotes tumor growth by modulating the tumor microenvironment through TGF-β and transcription factor pathways.

bioRxiv · May 15, 2024 · PreprintCancer Biology