Author

Jonathan H. Sussman

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metabolomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam BaggiD· 1 shared Adam Barsouk· 1 shared Alain H. RookiD· 1 shared Alberto CarturaniD· 1 shared Alireza DelfarahiD· 1 shared Andrew Evan Lee· 1 shared Antonia RotoloiD· 1 shared Antonio Imparato· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

Adam BaggORCID

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Author profile →

2 papers

Recent·Most cited

Harnessing the CD2 axis to broaden and enhance the efficacy of CAR T cell therapies

Alberto Carturan, Mathew G. Angelos, Puneeth Guruprasad, Ruchi P. Patel, Raymone Pajarillo, Andrew Evan Lee, Yunlin Zhang, Wei Xie, Jesse L. Rodriguez, Jaryse Harris, Pooja Devi, Olabisi I. Afolayan-Oloye, Jason Xu, Jonathan H. Sussman, Omar Elghawy, , Marco Ruella

This paper develops anti-CD2 CAR T-cells that overcome fratricide and improve efficacy by incorporating a PD-1:CD2 switch receptor to restore CD2 signaling.

Blood · Jan 5, 2026Peer-reviewedCancer Biology

AKT but not MYC promotes reactive oxygen species-mediated cell death in oxidative culture

Dongqing Zheng, Jonathan H. Sussman, Matthew P. Jeon, Sydney Parrish, Melanie A. MacMullan, Alireza Delfarah, Nicholas Alexander Graham

The paper shows that AKT, but not MYC, causes cell death in oxidative conditions by increasing reactive oxygen species, revealing a metabolic vulnerability in cancer cells.

Journal of Cell Science · Feb 24, 2020Peer-reviewedSystems Biology