S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling
Xin Geng, Keisuke Yanagida, Racheal Grace Akwii, Dongwon Choi, Lijuan Chen, Yen‐Chun Ho, Boksik Cha, Md. Riaj Mahamud, Karen Berman de Ruiz, Hirotake Ichise, Hong Chen, Joshua D. Wythe, Constantinos Marios Mikelis, Timothy Hla, R. Sathish Srinivasan
This study identifies S1PR1 as a regulator of lymphatic vessel quiescence by inhibiting LSS-dependent VEGF-C signaling in lymphatic endothelial cells.
JCI Insight · Jun 16, 2020Peer-reviewedDevelopmental Biology