Author

Ignacio Gallardo

University of Florida

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5

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Approach:experimental assay· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:electronic health records· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Mark S. MoehleiD· 5 shared Michael MillettiD· 5 shared Dominic HalliD· 4 shared Nicole ChambersiD· 4 shared Douglas Nabert· 3 shared Allison Comite· 2 shared Anika J. HeubergeriD· 2 shared Charlotte F. BrzozowskiiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersNeuroscience

Mark S. MoehleORCID

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5 papers

Recent·Most cited

α-Synuclein aggregates in corticostriatal terminals impair glutamatergic transmission in the absence of neurodegeneration

Charlotte F. Brzozowski, Zoe N. Fokakis, Marissa A. Menard, Harshita Challa, IGNACIO GALLARDO, J Dominic Hall, Douglas Narbert, Michael Millett, J. Andrew Hardaway, Mark S. Moehle, Laura A. Volpicelli‐Daley

This study shows that α-synuclein aggregates in corticostriatal terminals impair glutamatergic transmission without causing neurodegeneration.

bioRxiv · Aug 7, 2026 · PreprintNeuroscience

Pathological α-Synuclein Perturbs Nuclear Integrity

Michael Millett, Allison Comite, Elisabeth Martin Castosa, Anika J. Heuberger, Preston Wagner, Ignacio Gallardo, Jessica Reinhardt, Nicole Chambers, Dominic Hall, Evan Miller, Douglas Nabert, Barbara Balsamo, Stefan Prokop, Mark S. Moehle

This study shows pathological α-synuclein localizes in the nucleus, causing nuclear damage and dysfunction in synucleinopathy models and human tissue.

Neurobiology of Disease · Jul 15, 2025Peer-reviewedNeuroscience

Aggregated α-synuclein leads to corticostriatal synaptic dysfunction

Charlotte F. Brzozowski, Harshita Challa, Nolwazi Z. Gcwensa, Dominic Hall, Douglas Nabert, Nicole Chambers, Ignacio Gallardo, Michael Millett, Laura A. Volpicelli‐Daley, Mark S. Moehle

This study shows that aggregated α-synuclein impairs corticostriatal synaptic function and reduces synaptic density in mice, with some synapses showing increased volume.

bioRxiv · Jan 29, 2025 · PreprintNeuroscience

Conditional Knockout of Striatal Gnal Produces Dystonia-like Motor Phenotypes

Nicole Chambers, Dominic Hall, Stephanie Barsoum, Evan Miller, Tiffany Curry, Morgan Kaplan, Sarah Garan, Ignacio Gallardo, Rick Staab, Douglas Nabert, Kevin Hutchinson, Michael Millett, Mark S. Moehle

Knocking out Gnal in the striatum of mice leads to dystonia-like motor symptoms and increased excitability in striatal spiny projection neurons.

bioRxiv · Aug 26, 2024 · PreprintNeuroscience

Gαolf Regulates Biochemical Signaling in Neurons Associated with Movement Control and Initiation

Michael Millett, Anika J. Heuberger, Elisabeth Martin Castosa, Allison Comite, Preston Wagner, Dominic Hall, Ignacio Gallardo, Nicole Chambers, Lloyd Wagner, Mark S. Moehle

This study characterizes Gnal expression in the mouse brain and shows its role in motor-related neurons through conditional knockout experiments.

bioRxiv · Apr 3, 2024 · PreprintNeuroscience