Nicole Chambers

This study investigates the potential of M5 positive allosteric modulators to alleviate parkinsonian motor deficits without causing dyskinesia or impairing L-DOPA efficacy.

This study shows pathological α-synuclein localizes in the nucleus, causing nuclear damage and dysfunction in synucleinopathy models and human tissue.

This study shows that aggregated α-synuclein impairs corticostriatal synaptic function and reduces synaptic density in mice, with some synapses showing increased volume.

Knocking out Gnal in the striatum of mice leads to dystonia-like motor symptoms and increased excitability in striatal spiny projection neurons.

This study investigates the effect of M4 receptor activation in the pedunculopontine nucleus on L-DOPA-induced dyskinesia and motor function in hemiparkinsonian rats.

This study characterizes Gnal expression in the mouse brain and shows its role in motor-related neurons through conditional knockout experiments.