J. Hansen

Modulation of the GT Family 47 clade B gene affects arabinan deposition in elaters of Marchantia polymorpha

This paper investigates the role of GT47B genes in arabinan deposition in Marchantia polymorpha by analyzing mutants and overexpression lines, revealing reduced 1,5-L-arabinan in Mparadl2 mutants and challenges in purifying GT47B proteins.

Direct β1/β2 AMPK activation reduces liver steatosis but not fibrosis in a mouse model of non-alcoholic steatohepatitis

This study evaluates BI9774, an AMPK activator, in a mouse model of NASH, finding it reduces liver steatosis but not fibrosis and causes cardiac side effects.

BZR1 promotes pluripotency acquisition and callus development through direct regulation of ARF7 and ARF19

This study shows BZR1 promotes pluripotency and callus formation by directly regulating ARF7 and ARF19 in plants.

HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis

This study investigates how HSP60 deficiency disrupts mitochondrial proteostasis and dysregulates cholesterol synthesis, leading to developmental abnormalities and hypomyelination.

mTOR signaling controls the formation of smooth muscle cell-derived intimal fibroblasts during vasculitis.

This study identifies mTOR signaling as essential for the formation of SMC-derived intimal fibroblasts in vasculitis, offering a therapeutic target for vascular remodeling.

Bacterial assembly in the switchgrass rhizosphere is shaped by phylogeny, host genotype, and growing site.

The paper investigates how host genotype, phylogeny, and growing site shape bacterial composition in the switchgrass rhizosphere using genetic and microbial analyses.

ZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression

This study identifies ZBTB48 as a transcription factor that regulates B-cell-specific CIITA expression by binding to its promoter and establishing open chromatin.

Fibronectin-integrin α5 signaling promotes thoracic aortic aneurysm in a mouse model of Marfan syndrome

This study shows that fibronectin-integrin α5 signaling drives thoracic aortic aneurysms in Marfan syndrome mice, with a 5/2 chimera mutation reducing aneurysm severity.

Lipobiotin-capture magnetic bead assay for isolation, enrichment and detection of Mycobacterium tuberculosis from saliva

The paper introduces a lipobiotin-capture magnetic bead assay to enrich and detect Mycobacterium tuberculosis in saliva, improving detection rates in spiked samples and TB patient saliva.

Universal amyloidogenicity of patient-derivedimmunoglobulin light chains

This study shows that all tested patient-derived immunoglobulin light chains have comparable amyloidogenic potential, with proteolytic cleavage being a key determinant of in vivo aggregation.

A Library Of Induced Pluripotent Stem Cells From Clinically Well-Characterized, Diverse Healthy Human Individuals

The paper generates and characterizes a diverse library of hiPSCs from healthy humans for use in disease modeling and drug response studies.

The rise of the three-spined stickleback: eco-evolutionary consequences of a mesopredator release

The paper examines how the increase in three-spined stickleback due to declining perch populations has led to evolutionary and ecological changes in food web dynamics.

Condensed chromatin behaves like a solid on the mesoscale in vitro and in living cells

This study shows that chromatin behaves like a solid on the mesoscale both in vitro and in living cells, with solid-like properties maintained despite limited fiber interactions.

Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity: Mount Sinai DToxS LINCS Center Dataset

The paper generates proteomic signatures of kinase inhibitor-induced cardiotoxicity using high-throughput proteomics and integrates them with transcriptomic data to predict drug toxicity.

No evidence for disruption of global patterns of nest predation in shorebirds

The paper challenges claims of climate change disrupting nest predation patterns in shorebirds, arguing that the original study's methodology is flawed and lacks statistical support.

Whole cell response to receptor stimulation involves many deep and distributed subcellular processes

The paper identifies subcellular processes involved in cannabinoid-1 receptor regulated neurite outgrowth and shows they are distributed and deep.

Ecological strategy and genetic load in the shepherd's purse (Capsella bursa-pastoris) from the core and the limit of its natural range.

This study examines how genetic load and ecological strategies affect the performance of shepherd's purse accessions from the front and core of its range under competition.